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Home  >  References References General References Used Throughout Stability References Painful Injection From 50% Glycerin FDA Standardization Major Allergen And Standardization Regional Relevance Of Allergens Cross-Reactivity Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.… read more

Dosing One of the primary objectives when mixing allergenic extracts is to prepare a patient’s treatment set in a way that ensures an optimal therapeutic dose of each allergen in the patient’s allergen extract vial. Therefore, the limiting step when mixing is deciding what volume of each allergen to add to a patient’s maintenance vial.… read more

Profilin & Pan-Allergens Cross-reactivity is often seen between unrelated species due to shared minor allergens such as Profilin. A minor allergen is an allergenic protein that has demonstrated clinical sensitivity in a minority of patients in a population. Common allergens that demonstrate clinical sensitivity across unrelated species are known as Pan-Allergens. Profilin is a structual… read more

Major Allergen Characterization The active ingredients of allergenic extracts are the proteins that the immune system responds to. Within an extract, there may be multiple allergenic proteins. Major allergens are those proteins to which at least 50% of a population are sensitized to. Some of these allergens, such as Fel d 1 in cat, are… read more

Standardized Extracts The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between lots and manufacturers of the same extract. Extracts that have been standardized by the FDA include the northern pasture grasses (Timothy, June, Meadow Fescue, Orchard, Redtop, Perennial Rye, Sweet… read more

Potency Labeling The biologic strength (potency) of an allergenic extract can be expressed in a variety of ways. In general, all allergenic extracts are divided into 2 categories: Standardized (BAU /AU) The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between… read more